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Rotavirus
is highly prevalent, infecting virtually all children in the United States
by 5 years of age—many more than once.1
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In
a study conducted by Velázquez et al, virtually every child was infected
with rotavirus by 24 months of age. More than two thirds of children were
infected more than once. The cumulative probability of first and subsequent
rotavirus infections during the first 2 years of life is depicted in the
chart.2
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The rotavirus disease burden has historically been underestimated, partly due
to the fact that most healthcare providers do not test fecal specimens
for rotavirus.3
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Morbidity & Mortality |
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A
leading cause of severe acute gastroenteritis in infants and young children4
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Infects >95%
of infants and children by age 5 4
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Responsible
for more than $1 billion in direct and indirect medical costs each year5
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~1
in 17 children will require an emergency department visit*,6
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~1 in 70 children will require hospitalization*,7 |
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* In the first 5 years of life. Calculations are based on a US birth cohort of ~4 million and CDC
disease burden estimates.
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Estimated annual rotavirus
disease burden among children under 5 years of age, United States—Centers
for Disease Control and Prevention (CDC). 7
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| 1. |
Bernstein DI, Ward RL. Rotaviruses. In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Vol. 2. Philadelphia, Pa: Saunders; 2004;4:2110–2133
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| 2. |
Velázquez FR, Matson DO, Calva JJ, et al. Rotavirus infection in infants as a protection against subsequent infections. N Engl J Med. 1996;335:1022–1028.
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| 3. |
Hsu VP, Staat MA, Roberts N, et al. Use of active surveillance to validate international classification of diseases code estimates of rotavirus hospitalizations in children. Pediatrics. 2005;115:78–82.
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| 4. |
Parashar UD, Hummelman, EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003; 9:565-572. 5. Tucker AW, Haddix AC, Bresee JS, et al. JAMA. 1998;279:1371–1376.
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| 5. |
Tucker AW, Haddix AC, Bresee JS, et al. JAMA. 1998;279:1371–1376.
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| 6. |
Data available on request from Merck & Co., Inc., Professional Services-DAP, WP1-27, PO Box 4, West Point, PA 19486-0004. Please specify information package 20652084(1)–RTQ.
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| 7. |
Centers for Disease Control and Prevention. Prevention of rotavirus gastroenteritis among infants and children: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2006;55(RR-12):1–13.
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This site is intended only for healthcare professionals of the United States, its territories, and Puerto Rico.
RotaTeq is a registered trademark of Merck & Co., Inc.
20750348(2)-06/07-RTQ |
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